A reduction in mitochondrial activity has been strongly linked with various neurodegenerative diseases. Moreover, several mutations have been characterized that induce age-related mitochondrial malfunction. Scantox provides cell culture models that address the effect of compounds on mitochondrial activity and mitochondria related cell death in vitro.
Cell lines and primary neurons can be exposed to different toxins and examined for mitochondrial activity and mitochondrial membrane depolarization.
Effect of Mitochondrial Toxins and Ca2+ Influx on Mitochondrial Function
Compound testing for the following indications: