Meet QPS at Neuro4D, May 27-28, 2024, Mainz, Germany

Newsletter

B6.SOD1G93A Mouse Model Provides Extended Intervention Opportunities
QPS Neuropharmacology
B6.SOD1G93A transgenic mice, bred on a congenic C57BL/6 background, offer a compelling alternative to the commonly used SOD1(*G93A)1Gur mice. They exhibit a slightly slower progression of the amyotrophic lateral sclerosis (ALS)-specific phenotype compared to the original strain, which is conventionally bred on a mixed C57BL/6xSJL background. The slower disease course offers an extended window for …
Read More
Neuroinflammatory and oxidative stress response after AAV2 hA53T-α-syn injection
QPS Neuropharmacology
In a previous newsletter we already introduced the AAV2 hA53T-α-syn mouse model to present increased hA53T-α-syn levels in the unilaterally virus-injected substantia nigra and the caudate putamen of the same hemisphere compared to the contralateral hemisphere injected with control vector. Furthermore, we could show decreased tyrosine hydroxylase (TH) levels and increased Iba1 levels in the …
Read More
Patient-Derived Fibroblasts as Versatile Screening Tool for Lysosomal Storage Disease Research
QPS Neuropharmacology
We just established different patient-derived fibroblasts as models for various lysosomal storage diseases (LSDs), offering a valuable tool for drug screening. LSDs are a group of rare genetic disorders, characterized by deficiencies in specific enzymes that usually facilitate the lysosomal degradation process, leading to the accumulation of undegraded substances within the lysosome. These diseases can …
Read More
Search Strategy Analysis Details Morris Water Maze Readouts
QPS Neuropharmacology
We now offer advanced search strategy analysis of data gathered during Morris Water Maze (MWM) test without changes to the established protocol. The MWM has been a widely recognized method to analyze spatial navigation and learning for several decades. This makes it a valuable tool for the evaluation of cognitively impaired rodent models, used to …
Read More
Tau Phosphorylation Status of PS19 Mice as Model of Tauopathies
QPS Neuropharmacology
Newest results of our R&D team show highly increased total and phosphorylated tau (ptau) levels in transgenic PS19 mice already at early age. This rodent model for tauopathies expresses the T34 isoform and 4 microtubule binding repeats (1N4R) of the tau protein with P301S mutation under the regulatory control of the murine prion promoter (Prnp). …
Read More
12312 Next

Subscribe to our Newsletter

Name
Address
Confirmation*
This field is for validation purposes and should be left unchanged.

Newsletter