Amyotrophic Lateral Sclerosis (ALS) as progressive motor neuron disease is characterized by quickly progressing muscle atrophy and correlating motor symptoms. Degeneration of the upper and lower motor neurons of the spinal cord is the main cause for the observed motor decline and paralleled by strong neuroinflammation as observed by occurrence of astrocytosis and many activated …
Alzheimer’s Association International Conference, AAIC 2020
QPS will be exhibiting at Alzheimer’s Association International Conference, AAIC 2020 July 27-31, 2020 Visit our virtual booth to meet our team and learn more about how we can help to make your preclinical and clinical drug development process a success. We are available for a LIVE exhibit chat Monday – Thursday from 8:00-8:30 a.m. …
Alzheimer‘s Disease In Vitro and In Vivo Models at QPS Neuropharmacology
APPSL and 5xFAD mice for APP research and hTau, TMHT and PS19 mice for tau research offer a wide range of typical Alzheimer‘s disease pathologies. Furthermore, a whole series of in vitro systems is available for the analysis of APP and tau pathology, including cell free and different cellular models. The varying disease symptomatics of …
Discover Our New and Well-Validated Preclinical Services
Next to our complete preclinical study packages, QPS Neuropharmacology also offers stand-alone services to cover your research needs. Utilize tissue or cells of our transgenic animal models for histological labeling, biochemical analysis or cell culture or send us your own samples for analysis. The cell culture team of QPS Neuropharmacology now offers experiments in several …
In vitro model to study A53T α-synuclein in PD
Different preformed recombinant human α-synuclein (α-syn) fibrils were evaluated for their toxicity and seeding properties on primary cortical neurons in vitro. Our results show that monomeric human α-syn has no impact on cell viability, while preformed wild type and A53T human α-syn fibrils have toxic effects on primary cortical neurons. This toxic effect was exceeded …
