Amorfix Aggregated Aβ Assay (A4 Assay)


Assay format:
  • 96 well
Read-out:
  • Electrochemiluminescence
Application:
  • Brain homogenates
  • In vitro aggregated Aβ
  • CSF
Species:
  • Any

A4-assay-figure

Reduction of Aβ aggregation in hAPP transgenic mice treated with a β-secretase (BACE) inhibitor and a vaccine, respectively. (A) Dose-dependent effect of a novel BACE inhibitor on aggregated Aβ species in hippocampi of 8 months old male hAPPwt mice. Shown are mean + SEM, n=5. (B) Effect of a vaccine on aggregated Aβ species in hemibrains of 16 months old APP/Tg2576 mice. Shown are mean + SEM, n=8.

A4-Assay-Matrix