Models by MJFF

 

To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community with quick delivery and at low cost. QPS Neuropharmacology obtained the right to offer the following MJFF mouse models to its customers and would be happy to perform your study in these models.

 

Target Common Name Allele Type JAX strain Description Active link
LRRK1 LRRK1 KO Knockout 16120 knockout exons 24
throught 29 of Lrrk1
https://www.jax.org/strain/016120
LRRK1 LRRK1 KO Knockout 22880 knockout exons 24
throught 29 of Lrrk1, no
Pde6b
https://www.jax.org/strain/022880
LRRK1 and LRRK2 LRRK1/2 double KO Knockout 16122 knockout exons 24
throught 29 of Lrrk1 and
knockout exons 39
throught 40 of Lrrk2
https://www.jax.org/strain/016122
LRRK2 BAC Human LRRK2 wildtype Transgenic 13725 BAC transgene expresisng
WT LRRK2 enodgenouse
promotor
https://www.jax.org/strain/013725
LRRK2 BAC Human LRRK2 R1441G Transgenic 18786 BAC LRRK2(R1441G)
enodenous promotor
https://www.jax.org/strain/018786
LRRK2 BAC Human
LRRK2 G2019S
Transgenic 18785 BAC LRRK2 (G2019S)
transgene
https://www.jax.org/strain/018785
LRRK2 LRRK2 KO Knockout 16121 knockout exons 39
throught 40 of Lrrk2
https://www.jax.org/strain/016121
LRRK2 LRRK2 D1994A KI Knockin 21830 D1994A point mutation in
Lrrk2
https://www.jax.org/strain/021830
LRRK2 LRRK2 T1348N KI Knockin 21829 T1348N point mutation in
Lrrk2
https://www.jax.org/strain/021829
LRRK2 LRRK2 A2016T KI Knockin 21828 A2016T point mutation in
Lrrk2
https://www.jax.org/strain/021828
SNCA BAC Human alphasynuclein
wildtype
Transgenic 18442 BAC murine promotor
Human WT SNCA
https://www.jax.org/strain/018442
SNCA mThy-1 Human
alpha-synuclein
Transgenic 16936 Murine Thy1 promotor,
human WT SNCA
https://www.jax.org/strain/016936
SNCA mThy-1 Human
alpha-synuclein
Transgenic 17682 Murine Thy1 promotor,
human WT SNCA
https://www.jax.org/strain/017682
SNCA Alpha-synuclein KO Knockout 16123 knockout exons 1 through
4 of murine SNCA
https://www.jax.org/strain/016123
Eif4g1 Eif4g1 R1207H Knockin 24521 R1207H in exon 24, as
well as loxP sites flanking
exons 24 to 28. Crebmediated
recombination
removes exon 24 to 28
resulting in null allele.
https://www.jax.org/strain/024521
Eif4g1 Eif4g1 KO Conditional
Knockout
21827 LoxP sites flanking exons
24 to 28. Creb-mediated
recombination removed
exon 24 to 28 resulting in
null allele.
https://www.jax.org/strain/021827
VPS35 VPS35 D620N KI Knockin 23409 D620N mutation in exon 15 https://www.jax.org/strain/023409
VPS35 VPS35 D620N KIfloxΔneo
Vps35
Conditional
Knockout
21807 Cre recombinase inducible D620N mutation in exon 15 https://www.jax.org/strain/021807
GBA GBA D409V KI Knockin 19106 Gba D427V mutant
protein corresponse to
D409V
https://www.jax.org/strain/019106

 

 

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