QPS Austria now licensed the PS19 transgenic mouse from the University of Pennsylvania, USA (JAX 008169; Yoshiyama et al., 2007). The mouse expresses the T34 isoform and 4 microtubule binding repeats (1N4R) of the tau protein with P301S mutation under the regulatory control of the murine prion promoter (Prnp). PS19 mice are a popular model …
Enzyme and substrate measurements in the Gaucher disease mouse model 4L/PS-NA
QPS Austria is now able to offer Glucocerebrosidase (Gcase) activity as well as Glucosylceramide (GlcCer) and Glucosylsphingosine (GlcSph) measurements in your 4L/PS-NA study animals! These animals express the homozygous GbaV394L/V394L mutation (4L), have a complete prosaposin knockout (PS-) and a homozygous prosaposin transgene (NA) resulting in hypomorphic prosaposin levels. Measurement of GCase activity in brain …
GBA1 – Target in Neurodegenerative Diseases
GBA1 deficiency and mutations are related to Gaucher disease, but are also shown to be linked to neurodegenerative events, e.g. in Parkinsons disease. QPS Austria offers the analysis of GCase activity in various in vitro and in vivo models like 1. mouse embryonic fibroblasts (MEFs) of 4L/PS-NA mice and 2. CBE treated D-Line mice, respectively. …
