Biomarkers and their use in neurodegenerative disease research delineates a rising area of research and may provide an important link between preclinical disease models and evaluation of disease progression in patients. Neurofilament light chain (NF-L), a neuronal cytoplasmic protein, is increased in a variety of neuronal diseases due to axonal damage. A strong increase of …
Plaque-associated inflammation
Interested in plaque-associated inflammation? QPS Neuropharmacology is your partner for visualization and quantification of plaque-associated inflammation. Figure 1 shows an exemplary quantification process to evaluate microglia (Iba1 labeled) adjacent to amyloid-beta plaques (6E10 labeled). Multichannel immunofluorescence (up to four different antibodies plus DAPI labeling in one experiment), whole-slide imaging, and quantitative image analysis, allows detailed …
CAA – independent risk factor for cognitive dysfunction of Alzheimer’s disease
QPS Austria is your partner for visualization and quantification of Cerebral Amyloid Angiopathy (CAA) in murine tissues. Here we evaluated CAA in APPSL and 5xFAD transgenic animals by measuring the overlap of 6E10 and collagen IV labeling in the isocortex and hippocampus. The strongest progressive increase of CAA signal could be measured in APPSL mice …
R6/2 Mice – Late Stage Disease Model for Huntington’s Disease Research
R6/2 Mice express the N-terminal fragment of the human huntingtin (HTT) protein with ~120 CAG repeats under the control of the human HTT promoter. Animals are a highly used model for the development of drugs against Huntington’s disease. Mice present the following phenotype : 50 % survival at ~100 days Learning deficits at 10 weeks …
Neurofilament light chain – promising biomarker of neurodegeneration!
Neurofilament light chain (NF-L) is quantitatively the most common of three different neurofilament chains which constitute the backbone of the neuronal cytoskeleton. When neurodegeneration occurs or axons are damaged, NF-L has been shown to be present in cerebrospinal fluid and even plasma from patients. The importance of NF-L levels in CSF and plasma as peripheral …
