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Newsletter

Neuroinflammatory and oxidative stress response after AAV2 hA53T-α-syn injection
QPS Neuropharmacology
In a previous newsletter we already introduced the AAV2 hA53T-α-syn mouse model to present increased hA53T-α-syn levels in the unilaterally virus-injected substantia nigra and the caudate putamen of the same hemisphere compared to the contralateral hemisphere injected with control vector. Furthermore, we could show decreased tyrosine hydroxylase (TH) levels and increased Iba1 levels in the …
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Patient-Derived Fibroblasts as Versatile Screening Tool for Lysosomal Storage Disease Research
QPS Neuropharmacology
We just established different patient-derived fibroblasts as models for various lysosomal storage diseases (LSDs), offering a valuable tool for drug screening. LSDs are a group of rare genetic disorders, characterized by deficiencies in specific enzymes that usually facilitate the lysosomal degradation process, leading to the accumulation of undegraded substances within the lysosome. These diseases can …
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Search Strategy Analysis Details Morris Water Maze Readouts
QPS Neuropharmacology
We now offer advanced search strategy analysis of data gathered during Morris Water Maze (MWM) test without changes to the established protocol. The MWM has been a widely recognized method to analyze spatial navigation and learning for several decades. This makes it a valuable tool for the evaluation of cognitively impaired rodent models, used to …
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Tau Phosphorylation Status of PS19 Mice as Model of Tauopathies
QPS Neuropharmacology
Newest results of our R&D team show highly increased total and phosphorylated tau (ptau) levels in transgenic PS19 mice already at early age. This rodent model for tauopathies expresses the T34 isoform and 4 microtubule binding repeats (1N4R) of the tau protein with P301S mutation under the regulatory control of the murine prion promoter (Prnp). …
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Repeated electromyographic measurements for longitudinal evaluation of muscle impairments
QPS Neuropharmacology
We are now able to offer longitudinal, repeated in vivo electromyographic measurements in rodent models with motor impairment. These analyses provide sensitive longitudinal readouts about your drug candidates that are unaffected by the environmental or emotional status of your animals. Typical readouts are the Compound Muscle Action Potential (CMAP), Motor Unit Action Potential (MUAP) and …
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