Publications & Scientific References

Scientific References – Publications

Scantox

Scantox encourages its scientists to publish and disseminate the results of their high quality research which is mostly done in close collaboration with our clients.

The following articles are hyperlinked to the original journal article or an abstract of the article:

Gadolinium Presence in Rat Skin: Assessment of Histopathologic Changes Associated with Small Fiber Neuropathy

Boyken J, Lohrke J, Treu A, Neddens J, Jost G, Ulbrich H-F, Balzer T, Frenzel T, Prokesch M, Thuss U, Pietsch H.

Radiology, Vol. 310, No. 1; doi.org/10.1148/radiol.231984

Astaxanthin enhances autophagy, amyloid beta clearance and exerts anti-inflammatory effects in in vitro models of Alzheimer’s disease-related blood brain barrier dysfunction and inflammation

Adekunle Babalola J, Lang M, George M, Stracke A, Tam-Amersdorfer C, Itxaso I, Lucija D, Tadic J, Schilcher I, Loeffler T, Flunkert S, Prokesch M, Leitinger G, Lass A, Hutter-Paier B, Panzenboeck U, Hoefler G.

Brain Res. 2023 Aug 12:148518. doi: 10.1016/j.brainres.2023.148518. Online ahead of print. PMID: 37579986

Evaluating the effect of R-Baclofen and LP-211 on autistic behavior of the BTBR and Fmr1-KO mouse models

Shirin Sharghi, Stefanie Flunkert, Magdalena Daurer, Roland Rabl, Boris Philippe Chagnaud, Marcello Leopoldo, Enza Lacivita, Birgit Hutter-Paier and Manuela Prokesch.

Front. Neurosci. 17:1087788. 30. March 2023 doi: 0.3389/fnins.2023.1087788

Hydroxychloroquine lowers Alzheimer’s disease and related dementias risk and rescues molecular phenotypes related to Alzheimer’s disease

Vijay R Varma, Rishi J Desai, Sheeja Navakkode, Lik-Wei Wong, Carlos Anerillas, Tina Loeffler, Irene Schilcher, Mufaddal Mahesri, Kristyn Chin, Daniel B Horton, Seoyoung C Kim, Tobias Gerhard, Jodi B Segal, Sebastian Schneeweiss, Myriam Gorospe, Sreedharan Sajikumar, Madhav Thambisetty

Mol Psychiatry. 2022 Dec 28. doi: 10.1038/s41380-022-01912-0.

No association between initiation of phosphodiesterase-5 inhibitors and risk of incident Alzheimer’s disease and related dementia: results from the Drug Repurposing for Effective Alzheimer’s Medicines study

Rishi J Desai, Mufaddal Mahesri, Su Been Lee, Vijay R Varma, Tina Loeffler, Irene Schilcher, Tobias Gerhard, Jodi B Segal, Mary E Ritchey, Daniel B Horton, Seoyoung C Kim, Sebastian Schneeweiss, Madhav Thambisetty

Brain Communications, Volume 4, Issue 5, 2022, fcac247, doi: 10.1093/braincomms/fcac247

Leukotriene Signaling as a Target in α-Synucleinopathies

Katharina Strempfl, Michael S. Unger, Stefanie Flunkert, Andrea Trost, Herbert A. Reitsamer, Birgit Hutter-Paier and Ludwig Aigner

Biomolecules. 2022 Feb 23;12(3):346. doi: 10.3390/biom12030346

Impaired Retromer Function in Niemann-Pick Type C Disease Is Dependent on Intracellular Cholesterol Accumulation

Kristina Dominko, Ana Rastija, Sandra Sobocanec, Lea Vidatic, Sarah Meglaj, Andrea Lovincic Babic, Birgit Hutter-Paier, Alessio-Vittorio Colombo, Stefan F Lichtenthaler, Sabina Tahirovic, Silva Hecimovic

Int J Mol Sci. 2021 Dec 9;22(24):13256.doi: 10.3390/ijms222413256

Combination of the Glutaminyl Cyclase Inhibitor PQ912 (Varoglutamstat) and the Murine Monoclonal Antibody PBD-C06 (m6) Shows Additive Effects on Brain Aβ Pathology in Transgenic Mice

Torsten Hoffmann, Jens-Ulrich Rahfeld, Mathias Schenk, Falk Ponath, Koki Makioka, Birgit Hutter-Paier, Inge Lues, Cynthia A Lemere, Stephan Schilling

Int J Mol Sci. 2021 Oct 30;22(21):11791. DOI: 10.3390/ijms222111791

A brain proteomic signature of incipient Alzheimer’s disease in young APOE ε4 carriers identifies novel drug targets

Jackson A Roberts, Vijay R Varma, Yang An, Sudhir Varma, Julián Candia, Giovanna Fantoni, Vinod Tiwari, Carlos Anerillas, Andrew Williamson, Atsushi Saito, Tina Loeffler, Irene Schilcher, Ruin Moaddel, Mohammed Khadeer, Jacqueline Lovett, Toshiko Tanaka, Olga Pletnikova, Juan C Troncoso, David A Bennett, Marilyn S Albert, Kaiwen Yu, Mingming Niu, Vahram Haroutunian, Bin Zhang, Junmin Peng, Deborah L Croteau, Susan M Resnick, Myriam Gorospe, Vilhelm A Bohr, Luigi Ferrucci, Madhav Thambisetty

Sci Adv. 2021 Nov 12;7(46):eabi8178. DOI: 10.1126/sciadv.abi8178

CD4 + T cells contribute to neurodegeneration in Lewy body dementia

David Gate, Emma Tapp, Olivia Leventhal, Marian Shahid, Tim J Nonninger, Andrew C Yang, Katharina Strempfl, Michael S Unger, Tobias Fehlmann, Hamilton Oh, Divya Channappa, Victor W Henderson, Andreas Keller, Ludwig Aigner, Douglas R Galasko, Mark M Davis, Kathleen L Poston, Tony Wyss-Coray

Science. 2021 Oct 14;eabf7266. doi: 10.1126/science.abf7266