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TSPO as sensitive biomarker for neuroinflammation in the Huntingon’s disease mouse model R6/2

QPS Neuropharmacology

Neuroinflammation is a growing field of research in the fight against neurodegenerative diseases and other disorders affecting the central nervous system. TSPO is an outer mitochondrial membrane protein, that has recently raised some interest for research in Huntington’s disease since its upregulation has been associated with the activation of glia cells. By labelling GFAP, Iba1, and TSPO in the cortex of 8 and 15 week old R6/2 mice we show that immunolabeling of astrocytes is increased in 15 week old R6/2 mice while microglia do not change (A, B). Analysis of TSPO shows an increased immunoreactive area in R6/2 mice already at the age of 8 weeks that further increases at 15 weeks (C).


Figure 1. Neuroinflammation in R6/2 mice. Percent of cortical immunoreactive area covered by GFAP (A, astrocytes), Iba1 (B, microglia), and TSPO (C). Note the increase of GFAP and TSPO in older R6/2 mice. D and E: Immunofluorescence images show the expression of TSPO (green) in glia cells (red), examples show astrocytes in the corpus callosum (D) and microglia in the fornix (E).

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