The Morris water maze test is widely used to study spatial learning and memory. Animals are placed in a pool of water and have to swim to a hidden platform. Each mouse has to perform three trials on each of four consecutive days. After the last trial on day 4, mice have to fulfill a probe trial. During the probe trial, the platform is removed from the pool and the number of crossings over the former target position is recorded together with the abidance in the target quadrant.
Assessment of spatial learning of APPSL transgenic mice. MWM learning curves showing distance traversed and escape latencies during 4 testing days of 6 (A, D), 9 (B, E) and 12 month (C, F) old animals. 6 month old APPSL n = 19, ntg n = 21; 9 month old APPSL n = 21, ntg n = 19; 12 month old APPSL n = 13, ntg n = 22. Two-way ANOVA with Bonferroni ‘s post hoc test compared to ntg. *p<0.05; **p<0.01; ***p<0.001.