The Corridor Test is a sensitive system to measure sensorimotor impairment by unilateral damage to the dopaminergic system.
The apparatus consists of a long narrow corridor with 10 pairs of flanking jars. Each jar contains a sugar pellet. Animals are starved overnight and habituated to the corridor and the sugar pellets.
After habituation, sugar pellets are placed in the jars that are positioned at 5 cm intervals along the corridor always two jars next to each other. The animal is put in one corner of the corridor and videotaped while eating sugar pellets from the jars. The first 20 nose pokes are counted and the proportion between right and left jar are calculated. Adapted from Graelish et al. 2010; PMID: 20529122.
Number of nose pokes per side in the Corridor Test after a 6-OHDA lesion of one hemisphere. The dotted line represents number of evenly distributed nose pokes. Mean + SEM; sham: n = 16; 6-OHDA lesion: n = 26. One Way ANOVA: ***p<0.001.