The Grip Strength test is used to measure neuromuscular functions by determining the maximal peak force developed by a rat or mouse. Therefore, animals are placed on the grip strength apparatus so they are able to grab a small grid with their fore paws (in rats also measurement of hind paw strength is possible). Afterwards, the animal is slowly pulled away from the grid until it releases the handle.
The maximum strength of the animals grip is recorded.
Grip strength test of SOD1-G93A mice compared to non-transgenic mice. Shown is the force that animals can use to grip the handle in grams. Two-way ANOVA with Bonferroni’s post hoc test. Mean ± SEM; **p<0.01; ***p<0.001.