Pathological changes in axonal function are well known features of many neurological disorders. Nowadays, stimulation of axonal repair after injury is an important aspect for the development of new therapeutic drugs. The use of microfluidic chambers (MFCs) can provide unique insights into the axonal compartment independent of the soma. We thus established a model of …
Strong neuroinflammation in the induced EAE mouse model of Multiple Sclerosis
Multiple Sclerosis (MS) is a human specific disease and represents one of the most common neurological disorders among young adults. Although there is a broad range of neurological symptoms and different disease progressions, key hallmarks are demyelination, neuroinflammation, and neurodegeneration resulting in persistent invalidity. To model and test new drugs against MS, the Experimental Autoimmune …
Robust neuroinflammation in the Amyotrophic Lateral Sclerosis disease mouse model SOD1-G93A/low
Amyotrophic Lateral Sclerosis (ALS) as progressive motor neuron disease is characterized by quickly progressing muscle atrophy and correlating motor symptoms. Degeneration of the upper and lower motor neurons of the spinal cord is the main cause for the observed motor decline and paralleled by strong neuroinflammation as observed by occurrence of astrocytosis and many activated …
Alzheimer’s Association International Conference, AAIC 2020
QPS will be exhibiting at Alzheimer’s Association International Conference, AAIC 2020 July 27-31, 2020 Visit our virtual booth to meet our team and learn more about how we can help to make your preclinical and clinical drug development process a success. We are available for a LIVE exhibit chat Monday – Thursday from 8:00-8:30 a.m. …
Alzheimer‘s Disease In Vitro and In Vivo Models at QPS Neuropharmacology
APPSL and 5xFAD mice for APP research and hTau, TMHT and PS19 mice for tau research offer a wide range of typical Alzheimer‘s disease pathologies. Furthermore, a whole series of in vitro systems is available for the analysis of APP and tau pathology, including cell free and different cellular models. The varying disease symptomatics of …
