BTBR T+ Itpr3tf/J (BTBR) mice, a suitable animal model to study anxiety and repetitive behavior in Autism Spectrum Disorders (ASD)
In her FFG-funded PhD thesis at QPS Neuropharmacology in cooperation with Prof. Marcello Leopoldo from the University of Bari, Italy, Shirin Sharghi behaviorally characterized the BTBR T+ Itpr3tf/J mouse model of Autism Spectrum Disorders (ASD). BTBR T+ Itpr3tf/J mice were allocated to three different treatment groups of either LP-211 (a serotonergic compound), R-Baclofen (a GABAergic …
6neo mice closely mimic Pompe disease muscle pathology
The glycogen storage disease type II (GSD II) is a rare, multisystemic disease with variable rates of disease progression that is also called Pompe disease. It is caused by alterations in the acid α-glucosidase (GAA) gene, resulting in reduced levels of this enzyme that in turn leads to a reduced degradation and thus accumulation of …
Modelling the L-DOPA Priming Effect in Rats
Parkinson’s disease (PD) is characterized by reduced dopamine levels in the striatum causing severe motor deficits. Patients are thus often treated with L-DOPA, the precursor of catecholamines, including dopamine, but positive effects of this treatment fade with prolonged treatment resulting in dyskinesia. To model this priming effect of L-DOPA treatment in vivo, Wistar Han rats …
Activating Low Density Lipoprotein Receptor Related Protein 1 (LRP1) To Improve Aβ Clearance Through The Blood Brain Barrier
In his PhD project, Joshua Adekunle Babalola from the Medical University of Graz investigates the effect of astaxanthin on Aβ clearance and the functional consequences thereof. Transport across the blood-brain barrier (BBB) is an important mediator of beta-amyloid (Aβ) accumulation in the brain and a contributing factor in the pathogenesis of Alzheimer’s disease (AD). One …
Isolation of pure microglia from adult mice can improve your research: Validation in the 5xFAD mouse model
The importance of microglia, the resident brain macrophages, in neurodegenerative diseases is well-known and these cells are therefore frequently used as a target for new pharmacological interventions. At QPS Neuropharmacology, cell isolation of early postnatal microglia from mice is a well-established and standardized method for in vitro analysis of this specific cell type. In addition, …