Scientific References – Publications
QPS Neuropharmacology
QPS encourages its scientists to publish and disseminate the results of their high quality research which is mostly done in close collaboration with our clients.
The following articles are hyperlinked to the original journal article or an abstract of the article:
Impaired Retromer Function in Niemann-Pick Type C Disease Is Dependent on Intracellular Cholesterol Accumulation
Kristina Dominko, Ana Rastija, Sandra Sobocanec, Lea Vidatic, Sarah Meglaj, Andrea Lovincic Babic, Birgit Hutter-Paier, Alessio-Vittorio Colombo, Stefan F Lichtenthaler, Sabina Tahirovic, Silva Hecimovic
Int J Mol Sci. 2021 Dec 9;22(24):13256.doi: 10.3390/ijms222413256
Combination of the Glutaminyl Cyclase Inhibitor PQ912 (Varoglutamstat) and the Murine Monoclonal Antibody PBD-C06 (m6) Shows Additive Effects on Brain Aβ Pathology in Transgenic Mice
Torsten Hoffmann, Jens-Ulrich Rahfeld, Mathias Schenk, Falk Ponath, Koki Makioka, Birgit Hutter-Paier, Inge Lues, Cynthia A Lemere, Stephan Schilling
Int J Mol Sci. 2021 Oct 30;22(21):11791. DOI: 10.3390/ijms222111791
A brain proteomic signature of incipient Alzheimer’s disease in young APOE ε4 carriers identifies novel drug targets
Jackson A Roberts, Vijay R Varma, Yang An, Sudhir Varma, Julián Candia, Giovanna Fantoni, Vinod Tiwari, Carlos Anerillas, Andrew Williamson, Atsushi Saito, Tina Loeffler, Irene Schilcher, Ruin Moaddel, Mohammed Khadeer, Jacqueline Lovett, Toshiko Tanaka, Olga Pletnikova, Juan C Troncoso, David A Bennett, Marilyn S Albert, Kaiwen Yu, Mingming Niu, Vahram Haroutunian, Bin Zhang, Junmin Peng, Deborah L Croteau, Susan M Resnick, Myriam Gorospe, Vilhelm A Bohr, Luigi Ferrucci, Madhav Thambisetty
Sci Adv. 2021 Nov 12;7(46):eabi8178. DOI: 10.1126/sciadv.abi8178
CD4 + T cells contribute to neurodegeneration in Lewy body dementia
David Gate, Emma Tapp, Olivia Leventhal, Marian Shahid, Tim J Nonninger, Andrew C Yang, Katharina Strempfl, Michael S Unger, Tobias Fehlmann, Hamilton Oh, Divya Channappa, Victor W Henderson, Andreas Keller, Ludwig Aigner, Douglas R Galasko, Mark M Davis, Kathleen L Poston, Tony Wyss-Coray
Science. 2021 Oct 14;eabf7266. doi: 10.1126/science.abf7266
Characterization of an APP/tau rat model of Alzheimer’s disease by positron emission tomography and immunofluorescent labeling
Thomas Filip, Severin Mairinger, Joerg Neddens, Michael Sauberer, Stefanie Flunkert, Johann Stanek, Thomas Wanek, Nobuyuki Okamura, Oliver Langer, Birgit Hutter-Paier, Claudia Kuntner
Alzheimers Res Ther. 2021 Oct 16;13(1):175. doi: 10.1186/s13195-021-00916-2
Evaluation of Neuropathological Features in the SOD1-G93A Low Copy Number Transgenic Mouse Model of Amyotrophic Lateral Sclerosis
Agnes Molnar-Kasza†, Barbara Hinteregger†, Joerg Neddens, Roland Rabl, Stefanie Flunkert and Birgit Hutter-Paier
Front. Mol. Neurosci., 24 June 2021 | https://doi.org/10.3389/fnmol.2021.681868
Metabolic, Phenotypic, and Neuropathological Characterization of the Tg4-42 Mouse Model for Alzheimer’s Disease
Barbara Hinteregger, Tina Loeffler, Stefanie Flunkert, Joerg Neddens, Thomas A Bayer, Tobias Madl, Birgit Hutter-Paier
J Alzheimers Dis. 2021 Feb 25. doi: 10.3233/JAD-201204
The Leukotriene Receptor Antagonist Montelukast Attenuates Neuroinflammation and Affects Cognition in Transgenic 5xFAD Mice
Johanna Michael, Julia Zirknitzer, Michael Stefan Unger, Rodolphe Poupardin, Tanja Rieß, Nadine Paiement, Horst Zerbe, Birgit Hutter-Paier, Herbert Reitsamer, Ludwig Aigner
Int J Mol Sci. 2021 Mar 9;22(5):2782. doi: 10.3390/ijms22052782
Homozygosity of BACHD rats not only causes strong behavioral deficits in young female rats but also a reduced breeding success
Stephan Kurat, Petra Heinrich, Agnes Molnar-Kasza, Tina Loeffler, Stefanie Flunkert, Birgit Hutter-Paier
Brain Res. 2021 Mar 2;1761:147396. doi: 10.1016/j.brainres.2021.147396.
Bispecific Tau Antibodies with Additional Binding to C1q or Alpha-Synuclein
Wim Hendricus Quint, Irena Matečko-Burmann, Irene Schilcher, Tina Löffler, Michael Schöll, Björn Marcus Burmann, Thomas Vogels
J Alzheimers Dis. 2021 Feb 12. doi: 10.3233/JAD-201334