Scientific References – Publications
QPS Neuropharmacology
QPS encourages its scientists to publish and disseminate the results of their high quality research which is mostly done in close collaboration with our clients.
The following articles are hyperlinked to the original journal article or an abstract of the article:
Astaxanthin enhances autophagy, amyloid beta clearance and exerts anti-inflammatory effects in in vitro models of Alzheimer’s disease-related blood brain barrier dysfunction and inflammation
Adekunle Babalola J, Lang M, George M, Stracke A, Tam-Amersdorfer C, Itxaso I, Lucija D, Tadic J, Schilcher I, Loeffler T, Flunkert S, Prokesch M, Leitinger G, Lass A, Hutter-Paier B, Panzenboeck U, Hoefler G.
Brain Res. 2023 Aug 12:148518. doi: 10.1016/j.brainres.2023.148518. Online ahead of print. PMID: 37579986
Evaluating the effect of R-Baclofen and LP-211 on autistic behavior of the BTBR and Fmr1-KO mouse models
Shirin Sharghi, Stefanie Flunkert, Magdalena Daurer, Roland Rabl, Boris Philippe Chagnaud, Marcello Leopoldo, Enza Lacivita, Birgit Hutter-Paier and Manuela Prokesch.
Front. Neurosci. 17:1087788. 30. March 2023 doi: 0.3389/fnins.2023.1087788
Hydroxychloroquine lowers Alzheimer’s disease and related dementias risk and rescues molecular phenotypes related to Alzheimer’s disease
Vijay R Varma, Rishi J Desai, Sheeja Navakkode, Lik-Wei Wong, Carlos Anerillas, Tina Loeffler, Irene Schilcher, Mufaddal Mahesri, Kristyn Chin, Daniel B Horton, Seoyoung C Kim, Tobias Gerhard, Jodi B Segal, Sebastian Schneeweiss, Myriam Gorospe, Sreedharan Sajikumar, Madhav Thambisetty
Mol Psychiatry. 2022 Dec 28. doi: 10.1038/s41380-022-01912-0.
No association between initiation of phosphodiesterase-5 inhibitors and risk of incident Alzheimer’s disease and related dementia: results from the Drug Repurposing for Effective Alzheimer’s Medicines study
Rishi J Desai, Mufaddal Mahesri, Su Been Lee, Vijay R Varma, Tina Loeffler, Irene Schilcher, Tobias Gerhard, Jodi B Segal, Mary E Ritchey, Daniel B Horton, Seoyoung C Kim, Sebastian Schneeweiss, Madhav Thambisetty
Brain Communications, Volume 4, Issue 5, 2022, fcac247, doi: 10.1093/braincomms/fcac247
Leukotriene Signaling as a Target in α-Synucleinopathies
Katharina Strempfl, Michael S. Unger, Stefanie Flunkert, Andrea Trost, Herbert A. Reitsamer, Birgit Hutter-Paier and Ludwig Aigner
Biomolecules. 2022 Feb 23;12(3):346. doi: 10.3390/biom12030346
Impaired Retromer Function in Niemann-Pick Type C Disease Is Dependent on Intracellular Cholesterol Accumulation
Kristina Dominko, Ana Rastija, Sandra Sobocanec, Lea Vidatic, Sarah Meglaj, Andrea Lovincic Babic, Birgit Hutter-Paier, Alessio-Vittorio Colombo, Stefan F Lichtenthaler, Sabina Tahirovic, Silva Hecimovic
Int J Mol Sci. 2021 Dec 9;22(24):13256.doi: 10.3390/ijms222413256
Combination of the Glutaminyl Cyclase Inhibitor PQ912 (Varoglutamstat) and the Murine Monoclonal Antibody PBD-C06 (m6) Shows Additive Effects on Brain Aβ Pathology in Transgenic Mice
Torsten Hoffmann, Jens-Ulrich Rahfeld, Mathias Schenk, Falk Ponath, Koki Makioka, Birgit Hutter-Paier, Inge Lues, Cynthia A Lemere, Stephan Schilling
Int J Mol Sci. 2021 Oct 30;22(21):11791. DOI: 10.3390/ijms222111791
A brain proteomic signature of incipient Alzheimer’s disease in young APOE ε4 carriers identifies novel drug targets
Jackson A Roberts, Vijay R Varma, Yang An, Sudhir Varma, Julián Candia, Giovanna Fantoni, Vinod Tiwari, Carlos Anerillas, Andrew Williamson, Atsushi Saito, Tina Loeffler, Irene Schilcher, Ruin Moaddel, Mohammed Khadeer, Jacqueline Lovett, Toshiko Tanaka, Olga Pletnikova, Juan C Troncoso, David A Bennett, Marilyn S Albert, Kaiwen Yu, Mingming Niu, Vahram Haroutunian, Bin Zhang, Junmin Peng, Deborah L Croteau, Susan M Resnick, Myriam Gorospe, Vilhelm A Bohr, Luigi Ferrucci, Madhav Thambisetty
Sci Adv. 2021 Nov 12;7(46):eabi8178. DOI: 10.1126/sciadv.abi8178
CD4 + T cells contribute to neurodegeneration in Lewy body dementia
David Gate, Emma Tapp, Olivia Leventhal, Marian Shahid, Tim J Nonninger, Andrew C Yang, Katharina Strempfl, Michael S Unger, Tobias Fehlmann, Hamilton Oh, Divya Channappa, Victor W Henderson, Andreas Keller, Ludwig Aigner, Douglas R Galasko, Mark M Davis, Kathleen L Poston, Tony Wyss-Coray
Science. 2021 Oct 14;eabf7266. doi: 10.1126/science.abf7266
Characterization of an APP/tau rat model of Alzheimer’s disease by positron emission tomography and immunofluorescent labeling
Thomas Filip, Severin Mairinger, Joerg Neddens, Michael Sauberer, Stefanie Flunkert, Johann Stanek, Thomas Wanek, Nobuyuki Okamura, Oliver Langer, Birgit Hutter-Paier, Claudia Kuntner
Alzheimers Res Ther. 2021 Oct 16;13(1):175. doi: 10.1186/s13195-021-00916-2