QPS Neuropharmacology offers a broad selection of molecular biological methods for the analysis of various diseases. The unit supports in vitro and in vivo studies performed at QPS Neuropharmacology, although with the same techniques routine sample analyses from external preclinical or clinical studies are performed. Using the same analysis methods for preclinical in vitro and in vivo as well as clinical samples increased the translational value of your research project.
Specifics of the readouts depend on the indication. Please see the respective in vitro and in vivo models for the most relevant readout of each model.
For example, our main readout for AD is the analyses of different Aβ species. From animal models as well as from humans we routinely analyze brain and CSF samples for Aβ 38/40/42 and tau/ptau levels.
Additionally, A4 (Amorfix Aggregated Abeta Assay) – exclusively licensed to QPS Austria – serves as a unique screening tool, which enables the fast, highly sensitive and cost-efficient detection of Aβoligomers in diverse biological samples.
Furthermore, customized assays can be set up and validated, cloning and transfection of cell lines can be performed.