QPS Neuropharmacology offers a broad selection of molecular biological methods for the analysis of various diseases. The unit supports in vitro and in vivo studies performed at QPS Neuropharmacology, although with the same techniques routine sample analyses from external preclinical or clinical studies are performed. Using the same analysis methods for preclinical in vitro and in vivo as well as clinical samples increased the translational value of your research project.
Specifics of the readouts depend on the indication. Please see the respective in vitro and in vivo models for the most relevant readout of each model.
For example, our main readout for AD is the analyses of different Aβ species. From animal models as well as from humans we routinely analyze brain and CSF samples for Aβ 38/40/42 and tau/ptau levels.
Additionally, A4 (Amorfix Aggregated Abeta Assay) – exclusively licensed to QPS Austria – serves as a unique screening tool, which enables the fast, highly sensitive and cost-efficient detection of Aβoligomers in diverse biological samples.
Furthermore, customized assays can be set up and validated, cloning and transfection of cell lines can be performed.
We provide fast in-house processing by experienced and well-trained staff and work with highly reliable shipping companies to guarantee safe transfer of your valuable samples. In general, all kinds of S1 and S2 sample types can be analyzed. This includes samples from in-house or external in vivo studies (mouse/rat/guinea pig), samples from cell culture models (human, mouse, rat, chicken) or human subjects / patients from clinical studies.
Tissue samples are routinely prepared and fractionized according to established methods.
Our tissue sampling team is highly trained to dissect a plethora of different tissues from mice and rats. Different euthanasia and perfusion methods can be performed depending on your experimental needs. Can’t find what you are looking for? We are constantly establishing new methods and would be glad to develop dissections according to your requirements.