QPS Neuropharmacology offers a selection of molecular biological methods for the investigation of various diseases. The unit supports in vitro and in vivo studies performed at QPS Austria. However with the same techniques routine sample analyses from external preclinical or clinical studies is performed. Using the same methods for cell culture, animal and human samples brings your compound faster forward.
Specifics of the readouts depend on the indication. Please see the respective in vitro and in vivo models for the most relevant readout of each model.
For example our main readout for AD is the analyses of different Abeta species. In animal models as well as in humans we routinely analyze brain and CSF samples for Abeta 38/40/42 and tau/ptau levels.
Additionally, A4 (Amorfix Aggregated Abeta Assay) – exclusively licensed to QPS Austria – serves as a unique screening tool, which enables the fast, highly sensitive and cost efficient detection of Abeta oligomers in diverse biological samples.
Furthermore, customized assays can be set up and validated, cloning and transfection of cell lines can be performed.
We provide fast in-house processing by experienced and well-trained staff and work with highly reliable shipping companies to guarantee safe transfer of your valuable samples. In general all kinds of S1 and S2 sample types can be analyzed. This includes samples from in house or external in vivo studies (mouse/rat/guinea pig), samples from cell culture models (human, mouse, rat, chicken) or human subjects / patients from clinical studies.
Tissue samples are routinely prepared and fractionized according to established methods.