Experts in the field have debated for decades whether amyloid-beta or tau is the better target to cure Alzheimer’s Disease. We cannot answer this question but we can offer an extensive CRO service with transgenic mouse models for both aspects of the disease.
TMHT transgenic Mouse Model
hTau transgenic Mouse Model
PS19 transgenic Mouse Model
QPS Neuropharmacology offers custom tailored study design for these models and we are flexible to accommodate to your special interests. We are also happy to advice you and propose study designs. QPS Neuropharmacology maintains its own colonies directly in our research facility. Non-transgenic littermates are available as control animals needed for proper study design.
We would be happy to test your compounds in these mouse models!
Readouts depend on model but the most common are:
- Total tau and phosphorylated tau at different residues
- Learning and memory deficits (MWM)
Looking for something else? Please contact us!
You might be also interested in these related models:
- Tau seeding mouse model
- APPSL transgenic mouse model
- 5xFAD transgenic mouse model
- APP x hQC transgenic mouse model
- Scopolamine induced mouse model
As with all other in vivo models we are also ready to provide samples (brain tissue, CSF etc.) from these animals for analyses in your laboratory.