Cellular Imaging & Analysis - QPS Neuropharmacology

Cell culture models are analyzed for different parameters to characterize and quantify effects of test substances. Choose from our abundant supply of assays or let us help you to find the perfect solution for your screening assay using a customized Cellular Imaging and Analysis assay provided by QPS Austria.

Cell Survival

MTT
Calcein-AM
LDH

Cell Death

Necrosis (Propidium iodide)
Apoptosis (YOPRO, Caspase-3 activity, Mitochondria related assays)

ELISA / MSD

Abeta1-38, Abeta1-40, Abeta1-42, sAPP-alpha, sAPP-beta
Tau and phospho Tau profile
Signal transduction molecules
Inflammation markers (e.g. Prostaglandin E2)
Cytokine Profile

Immunofluorescences

Neuronal markers (beta-III tubulin, neurofilament, MAP2, tyrosine hydroxylase)‏
Glial markers (GFAP, CD11b)‏
Disease related markers (Tau, phosphorylated Tau, signaling molecules, synuclein)‏
Synaptic proteins (synaptophysin)

Western Blotting / WES

Synaptic proteins (glutamate receptor 1, NMDA receptors, synaptophysin, drebrin) e.g. from matured hippocampal neurons
Tau and phospho-Tau isoforms
Abeta peptide profile, Abeta aggregation assays
Cell signaling molecules
TDP43
Synuclein

Automated cellular imaging using macro-based software solutions

Area or object measurements (e.g. neurodegeneration of TH neurons, see also Histology)‏
Number of neurites, total length of neurites, length of longest neurite (e.g. Neurite Outgrowth)
BrdU positive neurons (e.g. Neurogenesis)

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Animal Models

QPS Neuropharmacology is highly experienced in generating, characterizing, and maintaining transgenic disease models and using them for drug testing projects for more than 20 years.

Behavioral Testing

QPS Neuropharmacology provides a wide range of behavioral tests for various indications. Most tests are evaluated using rater-independent digital animal tracking systems.

Histology Services

QPS Neuropharmacology offers a full set of histology services ranging from collection of tissue samples to delivering study reports that contain all experimental procedures and their outcome.

Biomarkers

QPS Neuropharmacology Department of Translational Medicine offers a selection of molecular biological methods for the investigation of various diseases. The unit supports in vitro and in vivo studies performed at QPS Austria.

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