APP Transgenic Mouse Models

Alzheimer’s disease (AD) is one of the most devastating neurodegenerative diseases of the 21st century. A disturbed APP metabolism (e.g. pathological aggregation of amyloid) in the brain of AD patients is thought to be one of the main causes of the observed progressive cognitive decline in affected people. The development of new AD drugs targeting APP related mechanisms is therefore one main focus in AD research. To be able to test these new drugs, appropriate animal models are needed.

Scantox currently offers several human APP transgenic mouse lines featuring different properties with regard to Aβ expression patterns, neuroinflammation, cognitive deficits, age at onset and progression of pathology. These animals focus on different pathological readouts and constitute suitable models to study the influence of drugs on APP-related brain pathology and behavior.

• APP_SL transgenic Mouse Model
• APP_SL x hQC transgenic Mouse Model
• 5xFAD transgenic Mouse Model
• Tg2576 Mouse Model

Scantox offers custom tailored study design for these models and we are flexible to accommodate to your special interests. We are also happy to advice you and propose study designs. Scantox maintains its own colonies directly in our research facility. Non-transgenic littermates are available as control animals needed for proper study design.

We would be happy to test your compounds in these mouse models! Readouts depend on model but the most common are:

Looking for something else? Please contact us!

You might be also interested in these related models:

• hTau transgenic mouse model
• TMHT transgenic mouse model
• PS19 transgenic mouse model
• Tau seeding model
• Scopolamine induced mouse model

As with all other in vivo models we are also ready to provide samples (brain tissue, CSF etc.) from these animals for analyses in your laboratory.

We are happy to receive your inquiry.