Alzheimer’s disease (AD) is one of the most devastating neurodegenerative diseases of the 21st century. A disturbed APP metabolism (e.g. pathological aggregation of amyloid) in the brain of AD patients is thought to be one of the main causes of the observed progressive cognitive decline in affected people. The development of new AD drugs targeting APP related mechanisms is therefore one main focus in AD research. To be able to test these new drugs, appropriate animal models are needed.
QPS Neuropharmacology currently offers eight human APP transgenic mouse lines featuring different properties with regard to Aβ expression patterns, neuroinflammation, cognitive deficits, age at onset and progression of pathology. These animals focus on different pathological readouts and constitute suitable models to study the influence of drugs on APP-related brain pathology and behavior.
APPSL transgenic Mouse Model
APPSL x hQC transgenic Mouse Model
ApoB x APP transgenic Mouse Model
5xFAD transgenic Mouse Model
Tg2576 Mouse Model
QPS Neuropharmacology offers custom tailored study design for these models and we are flexible to accommodate to your special interests. We are also happy to advice you and propose study designs. QPS Neuropharmacology maintains its own colonies directly in our research facility. Non-transgenic littermates are available as control animals needed for proper study design.
We would be happy to test your compounds in these mouse models! Readouts depend on model but the most common are:
- Aβ-38,-40 and -42 levels
- Aggregated Amyloid levels by A4 Assay
- Plaque load
- β-sheet load
- pE(3)-Aβ load
- Neurofilament Light Chain levels
- Neuronal loss
- Synaptic alterations
- Oxidative stress
- Cerebral vascular angiopathy (CAA)
- Phosphorylated tau
- Blood brain barrier homeostasis
- Learning and memory deficits (MWM)
Looking for something else? Please contact us!
You might be also interested in these related models:
- hTau transgenic mouse model
- TMHT transgenic mouse model
- PS19 transgenic mouse model
- Tau seeding model
- Scopolamine induced mouse model
As with all other in vivo models we are also ready to provide samples (brain tissue, CSF etc.) from these animals for analyses in your laboratory.